Kanamycin complexation with cellulose acetate sulphate: a promissing way from injectable to oral form of antibiotic

Water-insoluble polyelectrolyte complexes of cellulose acetate sulphate in the form sodium salt (Na-CAS) and aminoglycoside antibiotic (AB) kanamycin (KAN) were obtained by mixing components aqueous solutions. The composition was determined accordance with medium pH order. increase Na?CAS cellobiose units per mole AB has been shown to correlate decrease value. complex formation studied Fourier transform infrared spectroscopy, thermal analysis, X-ray laser diffraction, motion trajectory nanoparticles analysis scanning electron microscopy. Quantum-chemical study relative stability protonated forms KAN solution performed determine preferred protonation sites molecule. pKa values calculated means isodesmic reactions method. structures binding energy for dimer – CAS also investigated quantum-chemical methods. itself immobilised on activated carbon demonstrate vitro two times antibacterial activity standard (injectable) against Mycobacterium tuberculosis. It can be recommended vivo clinical trials as a new oral administration.